CD38 expression and Ig VH gene mutation in B-cell chronic lymphocytic leukemia.

predominance Hodgkin disease” and 69 as having “classic HD with lymphocyte depletion, rich in tumor cells.” None of the 278 patients with Hodgkin disease tested were found to express ALK. Our series has the advantage of representing a large number of cases having undergone panel review. This result, in accordance with most published results, does not support the hypothesis of HD and ALCL as histogenically related entities. Moreover, when the differential diagnosis is between HD rich in tumor cells and ALCL, our experience suggests that ALK expression by tumor cells argues against the former diagnosis.